硫化氢在胃黏膜损伤中的作用。
The role of hydrogen sulfide in gastric mucosal damage.
作者信息
Shen Fang, Zhao Chong-Shun, Shen Mei-Fen, Wang Zhong, Chen Gang
机构信息
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
出版信息
Med Gas Res. 2019 Apr-Jun;9(2):88-92. doi: 10.4103/2045-9912.260650.
Abstract
Gastrointestinal disease is a major global threat to public health. In the past few decades, numerous studies have focuses on the application of small molecule gases in the disease treatment. Increasing evidence has shown that hydrogen sulfide (HS) has anti-inflammatory and anti-oxidative effects, and can regulate gastric mucosal blood flow in the gastric mucosa. After gastric mucosa damage, the level of HS in the stomach decreases. Administration of HS can protect and repair the damaged gastric mucosa. Therefore, HS is a new target for the repair and treatment of gastric mucosa damage. In this review, we introduce the roles of HS in the treatment of gastric mucosa damage and provide the potential strategies for further clinical treatment.
摘要
胃肠道疾病是对全球公众健康的重大威胁。在过去几十年中，众多研究聚焦于小分子气体在疾病治疗中的应用。越来越多的证据表明，硫化氢（HS）具有抗炎和抗氧化作用，并且能够调节胃黏膜中的胃黏膜血流。胃黏膜损伤后，胃内的HS水平会降低。给予HS能够保护和修复受损的胃黏膜。因此，HS是胃黏膜损伤修复和治疗的新靶点。在本综述中，我们介绍了HS在胃黏膜损伤治疗中的作用，并提供了进一步临床治疗的潜在策略。
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