Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, La Jolla, CA.
Psychiatry Service, VA San Diego Healthcare, San Diego, CA.
Yale J Biol Med. 2019 Jun 27;92(2):251-258. eCollection 2019 Jun.
is the only single circadian clock gene that is essential for rhythmic gene expression in the mammalian circadian timing system. Genetic approaches targeting expression have been used to further assess its role in the circadian clock and to test for behavioral effects of clock disruption. In particular, disruptions in circadian clock function have been implicated in human mood disorders, and clock gene manipulation in mice may provide valuable models for studying depression-like behavior. In this review, we explore various approaches to manipulating in mouse models and review their effects on the brain's master circadian pacemaker, on circadian rhythmicity in other brain regions, and on circadian and mood-related behavior.
是哺乳动物昼夜节律计时系统中唯一必需的单个生物钟基因，用于节律基因表达。针对 表达的遗传方法已被用于进一步评估其在生物钟中的作用，并测试时钟中断的行为影响。特别是，昼夜节律时钟功能的中断与人类情绪障碍有关，并且在小鼠中对时钟基因的操作可能为研究类似抑郁的行为提供有价值的模型。在这篇综述中，我们探讨了在小鼠模型中操纵 的各种方法，并综述了它们对大脑主生物钟、其他大脑区域的昼夜节律性以及昼夜节律和情绪相关行为的影响。
