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两名心脏手术后发生Ⅱ型肝素诱导的血小板减少症患者出现巨大左心房血栓

Massive Left Atrial Thrombus in Two Patients with Heparin-Induced Thrombocytopenia Type II after Cardiac Surgery.

作者信息

Mandryk Yuriy, Czesla Markus, Mogilansky Christian, Stefkova Kristina, Drees Aloys, Massoudy Parwis

机构信息

Department of Cardiac Surgery, Klinikum Passau, Passau, Germany.

Department for Laboratory Medicine, Klinikum Passau, Passau, Germany.

出版信息

TH Open. 2018 Sep 26;2(3):e334-e337. doi: 10.1055/s-0038-1672188. eCollection 2018 Jul.

DOI:10.1055/s-0038-1672188
PMID:31249958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6524892/
Abstract

Heparin-induced thrombocytopenia type II (HIT type II) can have devastating consequences in cardiac surgical patients. We report two cases of massive left atrial thrombus after mitral valve replacement and endocardial cryoablation in patients with HIT type II.

摘要

II型肝素诱导的血小板减少症(II型HIT)可给心脏外科手术患者带来灾难性后果。我们报告了两例II型HIT患者在二尖瓣置换术和心内膜冷冻消融术后出现大量左心房血栓的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/997f/6524892/6e68617cea21/10-1055-s-0038-1672188-i180005-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/997f/6524892/cdb315baeb13/10-1055-s-0038-1672188-i180005-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/997f/6524892/0f865d832949/10-1055-s-0038-1672188-i180005-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/997f/6524892/6e68617cea21/10-1055-s-0038-1672188-i180005-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/997f/6524892/cdb315baeb13/10-1055-s-0038-1672188-i180005-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/997f/6524892/0f865d832949/10-1055-s-0038-1672188-i180005-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/997f/6524892/6e68617cea21/10-1055-s-0038-1672188-i180005-3.jpg

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本文引用的文献

1
Giant left ventricular thrombus formation associated with heparin-induced thrombocytopenia.与肝素诱导的血小板减少症相关的巨大左心室血栓形成
Ann Thorac Surg. 2014 Dec;98(6):e143-5. doi: 10.1016/j.athoracsur.2014.08.054. Epub 2014 Dec 1.
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Recurrent left atrial and left ventricular thrombosis due to heparin-induced thrombocytopenia: case report and short review.肝素诱导的血小板减少症导致的复发性左心房和左心室血栓形成:病例报告及简要综述
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Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia.755例连续送检进行肝素诱导的血小板减少症诊断检测的患者样本中IgG、IgM和IgA类抗PF4/肝素抗体的发生率及临床意义。
Eur J Haematol. 2006 May;76(5):420-6. doi: 10.1111/j.1600-0609.2005.00621.x. Epub 2006 Feb 6.
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Circulation. 2005 Aug 30;112(9 Suppl):I1-6. doi: 10.1161/CIRCULATIONAHA.104.524363.
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Thrombosis of a mitral valve prosthesis in a patient with heparin-induced thrombocytopenia type II.一名患有II型肝素诱导的血小板减少症患者的二尖瓣人工瓣膜血栓形成。
J Thorac Cardiovasc Surg. 1999 Oct;118(4):751-3. doi: 10.1016/S0022-5223(99)70025-5.
10
Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin.接受低分子量肝素或普通肝素治疗的患者发生肝素诱导的血小板减少症。
N Engl J Med. 1995 May 18;332(20):1330-5. doi: 10.1056/NEJM199505183322003.