Hudspeth A J, Jacobs R
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1506-9. doi: 10.1073/pnas.76.3.1506.
The vertebrate hair cell is a sensory receptor that responds to mechanical stimulation of its hair bundle, which usually consists of numerous large microvilli (stereocilia) and a single true cilium (the kinocilium). We have examined the roles of these two components of the hair bundle by recording intracellularly from bullfrog saccular hair cells. Detachment of the kinocilium from the hair bundle and deflection of this cilium produces no receptor potentials. Mechanical stimulation of stereocilia, however, elicits responses of normal amplitude and sensitivity. Scanning electron microscopy confirms the assessments of ciliary position made during physiological recording. Stereocilia mediate the transduction process of the vertebrate hair cell, while the kinocilium may serve primarily as a linkage conveying mechanical displacements to the stereocilia.
脊椎动物的毛细胞是一种感觉受体，对其毛束的机械刺激作出反应，毛束通常由许多大的微绒毛（静纤毛）和一根真正的纤毛（动纤毛）组成。我们通过对牛蛙球囊毛细胞进行细胞内记录，研究了毛束这两个组成部分的作用。动纤毛从毛束上脱离以及该纤毛的偏转均不会产生感受器电位。然而，对静纤毛的机械刺激会引发正常幅度和灵敏度的反应。扫描电子显微镜证实了生理记录过程中对纤毛位置的评估。静纤毛介导脊椎动物毛细胞的转导过程，而动纤毛可能主要作为一种将机械位移传递给静纤毛的连接结构。
