Smith R B, Sachan D S, Plattsmier J, Feld N, Lorch V
Department of Nutrition, University of Tennessee, Knoxville.
JPEN J Parenter Enteral Nutr. 1988 Jan-Feb;12(1):37-42. doi: 10.1177/014860718801200137.
Plasma carnitine, carnitine esters, and triglyceride concentrations were determined in 36 appropriate-forgestational-age (AGA) infants at various stages of prematurity throughout hospitalization to determine the effect of a carnitine-free and carnitine-containing diet on plasma carnitine and triglyceride concentrations. The infants were entered into one of three experimental groups based on birth weight: group I less than 1.0 kg; group II 1.0-1.51 kg; and group III 1.52-2.5 kg. Throughout the study subjects were placed on appropriate nutritional regimes which included hyperalimentation (HA), intravenous (iv) fat emulsion (Intralipid), Portagen, Enfamil-24 Premature Formula, Enfamil-20, and breastmilk. Blood samples were drawn from each infant at birth, days 1-5,7 then weekly, also before and after each nutritional intervention to determine carnitine and triglyceride concentrations. Results showed that plasma total carnitine and nonesterified carnitine decreased in all groups when the infants were maintained on a carnitine-free diet (HA, Intralipid, Portagen). In general, the carnitine levels continued to decrease until a carnitine-containing diet was initiated. Once a carnitine-containing diet was begun, plasma total carnitine (TC) and nonesterified carnitine (NEC) levels increased at fairly similar rates in all groups. However, an inverse relationship between carnitine and triglyceride (TG) concentrations were not seen in these infants. This would indicate that most premature infants require exogenous carnitine to maintain the plasma concentration of carnitine. However, a decreased concentration of plasma carnitine was not correlated with an elevated TG level under the conditions of this study.
在整个住院期间，对36名不同早产阶段的适于胎龄（AGA）婴儿测定血浆肉碱、肉碱酯和甘油三酯浓度，以确定不含肉碱和含肉碱饮食对血浆肉碱和甘油三酯浓度的影响。根据出生体重，将婴儿分为三个实验组之一：第一组体重小于1.0kg；第二组体重1.0 - 1.51kg；第三组体重1.52 - 2.5kg。在整个研究过程中，受试者接受适当的营养方案，包括胃肠外营养（HA）、静脉注射（iv）脂肪乳剂（英脱利匹特）、纽迪希亚早产奶粉、美赞臣24早产配方奶粉、美赞臣20奶粉和母乳。在出生时、第1 - 5天、第7天，然后每周，以及每次营养干预前后，从每个婴儿采集血样，以测定肉碱和甘油三酯浓度。结果显示，当婴儿维持不含肉碱的饮食（HA、英脱利匹特、纽迪希亚早产奶粉）时，所有组的血浆总肉碱和非酯化肉碱均下降。一般来说，肉碱水平持续下降，直到开始含肉碱的饮食。一旦开始含肉碱的饮食，所有组的血浆总肉碱（TC）和非酯化肉碱（NEC）水平以相当相似的速率增加。然而，在这些婴儿中未发现肉碱与甘油三酯（TG）浓度之间的负相关关系。这表明大多数早产儿需要外源性肉碱来维持血浆肉碱浓度。然而，在本研究条件下，血浆肉碱浓度降低与TG水平升高无关。
