Centre for Personalized Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner College and Cooper Roads (Bldg 75), The University of Queensland, Brisbane, QLD 4072, Australia.
Centre for Personalized Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner College and Cooper Roads (Bldg 75), The University of Queensland, Brisbane, QLD 4072, Australia.
Trends Mol Med. 2019 Nov;25(11):955-966. doi: 10.1016/j.molmed.2019.05.014. Epub 2019 Jun 25.
Eukaryotic cell DNA conserves a distinct genomic methylation pattern, which acts as a molecular switch to control the transcriptional machinery of the cell. However, pathological processes can alter this methylation pattern, leading to the onset of diseases such as cancer. Recent advances in methylation analysis provide a more precise understanding of the consequence of DNA methylation changes towards cancer progression. Consequently, the discoveries of numerous methylation-based biomarkers have inspired the development of simple tests for cancer detection. In this opinion article, we systematically discuss the benefits and challenges associated with the promising methylation-based approaches and develop a point-of-care index to evaluate their potential in terms of point-of-care cancer diagnostics.
真核细胞的 DNA 保持着独特的基因组甲基化模式，这种模式充当分子开关，控制着细胞的转录机制。然而，病理过程可以改变这种甲基化模式，导致癌症等疾病的发生。近年来，甲基化分析的进展提供了对 DNA 甲基化变化对癌症进展影响的更精确理解。因此，许多基于甲基化的生物标志物的发现激发了用于癌症检测的简单测试的开发。在这篇观点文章中，我们系统地讨论了基于甲基化的有前途的方法的优势和挑战，并开发了一个即时护理指数来评估它们在即时护理癌症诊断方面的潜力。
