花生四烯酸级联抑制剂对豚鼠回肠肌间神经丛乙酰胆碱释放的调节作用

Modulation of acetylcholine release from guinea-pig Ileum myenteric plexus by arachidonic acid cascade inhibitors.

作者信息

Takeuchi T, Yagasaki O

机构信息

Department of Veterinary Pharmacology, College of Agriculture, University of Osaka Prefecture, Sakai, Japan.

出版信息

Jpn J Pharmacol. 1987 Nov;45(3):434-7. doi: 10.1254/jjp.45.434.

DOI:10.1254/jjp.45.434

PMID:3125372

Abstract

Effects of arachidonic acid and mepacrine on ACh release from guinea-pig ileum myenteric plexus were investigated. Mepacrine (1-8 microM) inhibited the ACh release in a concentration-dependent manner. Arachidonic acid counteracted the inhibitory effect of mepacrine, but PGE2 did not. The inhibition induced by a combination of mepacrine and indomethacin on nicotine-induced ACh release was prevented by arachidonic acid, while that on spontaneous ACh release was prevented by arachidonic acid and PGE2 added simultaneously. The roles of arachidonic acid and PGs in the ACh release will be discussed.

摘要

研究了花生四烯酸和米帕林对豚鼠回肠肌间神经丛乙酰胆碱释放的影响。米帕林（1-8微摩尔）以浓度依赖的方式抑制乙酰胆碱释放。花生四烯酸抵消了米帕林的抑制作用，但前列腺素E2没有。米帕林和吲哚美辛联合对尼古丁诱导的乙酰胆碱释放的抑制作用可被花生四烯酸阻止，而对自发性乙酰胆碱释放的抑制作用可被同时添加的花生四烯酸和前列腺素E2阻止。将讨论花生四烯酸和前列腺素在乙酰胆碱释放中的作用。