生物制剂在膝关节病变中的临床应用：患者是否获益？
The Clinical Use of Biologics in the Knee Lesions: Does the Patient Benefit?
作者信息
Cengiz Ibrahim Fatih, Pereira Hélder, Espregueira-Mendes João, Reis Rui L, Oliveira Joaquim Miguel
机构信息
3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal.
ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal.
出版信息
Curr Rev Musculoskelet Med. 2019 Jun 28;12(3):406-414. doi: 10.1007/s12178-019-09573-3.
PURPOSE OF REVIEW
Overview the outcomes of the latest use of platelet-rich plasma (PRP) for the treatment of knee lesions in the clinics and discuss the challenges and limitations.
RECENT FINDINGS
Recent clinical studies mainly indicate there may be benefit of PRP usage for the treatment of knee lesions. As an autologous source of bioactive components, PRP has been shown to be typically safe, free of major adverse outcomes. The use of PRP has been continuously increasing, and some well-designed, double-blinded, placebo-controlled clinical trials have been published. Clinical outcomes relating to PRP usage are multifactorial and depend on the severity of the lesion and patient characteristics. Although PRP is safe to use and it can be easily applied in the clinics, case-specific considerations are needed to determine whether PRP could be beneficial or not. If the use of PRP is favored, then, the configuration/optimization of the preparation and administration/delivery strategy with or without a concomitant treatment may further enhance the clinical outcomes and patients' experience.
综述目的
概述富血小板血浆（PRP）在临床中治疗膝关节损伤的最新应用成果，并讨论其面临的挑战和局限性。
最新发现
近期临床研究主要表明，使用PRP治疗膝关节损伤可能有益。作为生物活性成分的自体来源，PRP已被证明通常是安全的，无重大不良后果。PRP的使用一直在不断增加，并且已经发表了一些设计良好、双盲、安慰剂对照的临床试验。与PRP使用相关的临床结果是多因素的，取决于损伤的严重程度和患者特征。尽管PRP使用安全且易于在临床中应用，但需要根据具体情况考虑以确定PRP是否有益。如果倾向于使用PRP，那么，制剂的配置/优化以及给药/递送策略（无论是否伴随其他治疗）可能会进一步提高临床疗效和患者体验。
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