Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France; Department of Hematology-Oncology, Hotel Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
University of Ioannina, Ioannina, Greece.
Cancer Epidemiol. 2019 Aug;61:139-141. doi: 10.1016/j.canep.2019.06.006. Epub 2019 Jun 26.
Cancer of unknown primary (CUP) is a heterogeneous group of metastatic cancers for which a primary tumor cannot be identified after a standardized work-up. The biology of CUP has not been fully elucidated and epidemiologic data may be helpful in this regard. The variations in the incidence-rate over time and between countries reflect changes in the risk factors for CUP, incidence trends of the primary tumors that potentially contribute to the burden of CUP and changes in the diagnostic technologies and practice. CUP accounted for 3-5% of cancers in the historical series but its incidence seems to decline in the recent publications. This paper reviews the published cancer-registry studies in order to identify and understand the variations in the incidence-rates of CUP.
原发灶不明的癌症（CUP）是一组异质性转移性癌症，经过标准化检查后仍无法确定原发性肿瘤。CUP 的生物学特性尚未完全阐明，而流行病学数据在这方面可能会有所帮助。发病率随时间和国家的变化反映了 CUP 危险因素的变化、可能导致 CUP 负担的原发性肿瘤的发病趋势以及诊断技术和实践的变化。在历史系列中，CUP 占癌症的 3-5%，但其发病率在最近的出版物中似乎有所下降。本文综述了已发表的癌症登记研究，以确定和理解 CUP 发病率的变化。
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