OBJECTIVES: The objective of this study is to conduct a systematic review to summarise currently implemented interventions, investigating their effectiveness in reducing alcohol use and sexual risk taking behaviour in teenagers and young adults. STUDY DESIGN: This is a systematic review. METHODS: Studies published in English language with both alcohol and sexual risky behaviour reduction interventions were searched using five electronic database platforms. All review tasks such as study screening, selection, data extraction, quality rating and synthesis were performed in accordance with systematic review guidelines. RESULTS: The review included 18 studies. Fifteen studies were randomised control trials (RCTs), whereas three were interventional studies having pre-intervention and postintervention analysis. Overall study duration ranged from 6 months to 24 months. The retention rate decreased with an increase in study duration and ranged from 60% to 80% for majority of studies, whereas some studies particularly planned for a shorter period had a higher retention rate (≥90%). The study site showed a range of patterns (in schools/college = 5, at family level/home environment = 3, web based = 2, sexual health clinics = 2, mental health clinics = 1, community level = 1 and juvenile detention facility = 4). The study quality assessment showed that most studies were of medium to high quality. Evidence from this systematic review suggests that after interventions, young people are less likely to engage in risky sexual behaviour and choose harmful alcohol drinking. The major factors influencing individuals during adolescence and early adulthood include local cultural norms, acceptability of casual sex and binge drinking trends in the teenage and young communities. It was also observed that study setting and target population determine the type of intervention required and impacts on outcomes. CONCLUSIONS: This review suggests that interventions to reduce risky sexual behaviour and alcohol consumption work in teenagers and young adults. However, selection of appropriate intervention type/design, delivery methods and follow-up plans are key elements to ensure both uptake and success of such intervention projects.