直接口服抗凝剂与急性肾损伤：阿哌沙班诱发的急性间质性肾炎。
Direct oral anticoagulant and AKI: apixaban-induced acute interstitial nephritis.
作者信息
DiMaria Christina, Hanna Wael, Murone Julie, Reichart James
机构信息
Internal Medicine, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA.
Hospital Medicine, Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, USA.
出版信息
BMJ Case Rep. 2019 Jun 29;12(6):e230371. doi: 10.1136/bcr-2019-230371.
Abstract
Direct oral anticoagulants (DOACs)-dabigatran, rivaroxaban, apixaban and edoxaban-are changing the landscape of clinical practice for patients requiring short and long-term anticoagulation. We report a patient with no history of kidney disease developing acute interstitial nephritis (AIN) after starting a DOAC, apixaban. To date, this is the first biopsy proven case of apixaban-induced AIN.
摘要
直接口服抗凝剂（DOACs）——达比加群、利伐沙班、阿哌沙班和依度沙班——正在改变需要短期和长期抗凝治疗患者的临床实践格局。我们报告了一名无肾脏疾病史的患者，在开始服用DOAC阿哌沙班后发生了急性间质性肾炎（AIN）。迄今为止，这是首例经活检证实的阿哌沙班所致AIN病例。
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