Luo Ming-Ya, Guo Zhen-Ni, Qu Yang, Zhang Peng, Wang Zan, Jin Hang, Ma Hong-Yin, Lv Shan, Sun Xin, Yang Yi
Department of Neurology, First Hospital of Jilin University, Chang Chun, China.
Clinical Trial and Research Center for Stroke, Department of Neurology, First Hospital of Jilin University, Chang Chun, China.
Front Psychiatry. 2019 May 31;10:373. doi: 10.3389/fpsyt.2019.00373. eCollection 2019.
Patients with depression tend to have various comorbid neurological symptoms, but the mechanisms remain unclear. The purpose of this study was to analyze the characteristics of dynamic cerebral autoregulation in depressed patients. Patients (aged ≥ 18 years) who were diagnosed with depression [17-item Hamilton Depression Rating Scale (HAMD) > 17] or suspected of depression (HAMD > 7) were enrolled in this study. Medically healthy volunteers were recruited as controls. The subjects also received the 7-item HAMD. We simultaneously recorded noninvasive continuous arterial blood pressure and bilateral middle cerebral artery blood flow velocity from each subject. Cerebral autoregulation was assessed by analyzing the phase difference using transfer function analysis. This study enrolled 54 patients with suspected depression, 45 patients with depression, and 48 healthy volunteers. The mean phase difference values were significantly lower in the patients with depression (F = 9.071, P < 0.001). In the multiple regression analysis, depression was negatively correlated with the phase difference values. Dynamic cerebral autoregulation was compromised in patients with depression and negatively correlated with the depression score. Improving dynamic cerebral autoregulation may be a potential therapeutic method for treating the neurological symptoms of depression.
抑郁症患者往往伴有各种共病性神经症状，但其机制尚不清楚。本研究的目的是分析抑郁症患者动态脑自动调节的特征。本研究纳入了年龄≥18岁、被诊断为抑郁症（17项汉密尔顿抑郁量表[HAMD]>17）或疑似抑郁症（HAMD>7）的患者。招募身体健康的志愿者作为对照。受试者还接受了7项HAMD评估。我们同时记录了每位受试者的无创连续动脉血压和双侧大脑中动脉血流速度。通过传递函数分析相位差来评估脑自动调节。本研究纳入了54例疑似抑郁症患者、45例抑郁症患者和48名健康志愿者。抑郁症患者的平均相位差值显著更低（F = 9.071，P < 0.001）。在多元回归分析中，抑郁症与相位差值呈负相关。抑郁症患者的动态脑自动调节受损，且与抑郁评分呈负相关。改善动态脑自动调节可能是治疗抑郁症神经症状的一种潜在治疗方法。
