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儿童惊厥性癫痫持续状态的病因及预后

Etiology and outcomes of convulsive status epilepticus in children.

作者信息

Uzair Muhammad, Ibrahim Asif, Zafar Faisal, Sultan Tipu

机构信息

Dr. Muhammad Uzair MBBS, FCPS (Pediatrics), Fellow Pediatrics Neurology, Department of Pediatric Neurology, Children Hospital Lahore, Pakistan.

Dr. Asif Ibrahim MBBS, FCPS (Pediatrics), Fellow Pediatrics Neurology. , Department of Pediatric Neurology, Children Hospital Lahore, Pakistan.

出版信息

Pak J Med Sci. 2019;35(3):620-623. doi: 10.12669/pjms.35.3.120.

Abstract

OBJECTIVE

The study aimed to ascertain different causes and outcomes of convulsive status epilepticus in children.

METHODS

From January 2018 to June 2018, seventy three patients who presented with status epilepticus were studied. Data were recorded with the help of a pre-formed performa. Etiological factors and outcomes in terms of recovery, morbidity and mortality were studied.

RESULTS

Out of 73 children, forty one (56%) were males and 32(44%) were females with median age of 1.09±0.27 years. Etiologies were acute symptomatic 25(34%), febrile 19(26%), progressive encephalopathy 10(14%), remote symptomatic 10(14%) and idiopathic 7 (9%) with p-value 0.005. Status epilepticus was controlled within one hour in 42(57%), within 1-6 hours in 21(29%) and more than 6 hours in 10(14%) patients with p-value 0.027. During hospitals stay, twenty one (29%) patients recovered completely, seizure recurred in 12(16%), Twelve (16%) became mentally retarded, Twelve (16%) developed mental retardation along with seizures and 16(22%) died. Eight (10.9%) deaths were attributed to acute symptomatic etiology with p-value less than 0.001.

CONCLUSION

This study concluded that acute symptomatic etiology was more common cause of status epilepticus as compared to other etiologies and it is associated with poorer outcomes as compared to other etiologies.

摘要

目的

本研究旨在确定儿童惊厥性癫痫持续状态的不同病因及预后。

方法

对2018年1月至2018年6月期间出现癫痫持续状态的73例患者进行研究。借助预先制定的表格记录数据。研究病因以及恢复、发病和死亡方面的预后情况。

结果

73名儿童中,41名(56%)为男性,32名(44%)为女性,中位年龄为1.09±0.27岁。病因包括急性症状性25例(34%)、热性19例(26%)、进行性脑病10例(14%)、远期症状性10例(14%)和特发性7例(9%),p值为0.005。42例(57%)患者的癫痫持续状态在1小时内得到控制,21例(29%)在1至6小时内得到控制,10例(14%)患者超过6小时才得到控制,p值为0.027。住院期间,21例(29%)患者完全康复,12例(16%)癫痫复发,12例(16%)智力发育迟缓,12例(16%)智力发育迟缓并伴有癫痫发作,16例(22%)死亡。8例(10.9%)死亡归因于急性症状性病因,p值小于0.001。

结论

本研究得出结论,与其他病因相比,急性症状性病因是癫痫持续状态更常见的病因,且与其他病因相比,其预后较差。

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