-吡咯基(呋喃基)取代哌嗪、1,4-二氮杂双环[2.2.2]辛烷和 1,4-二氮杂环庚烷的合成。
Synthesis of -Pyrrolyl(furanyl)-Substituted Piperazines, 1,4-Dizepanes, and 1,4-Diazocanes.
机构信息
Núcleo de Química de Heterociclos (NUQUIMHE), Departamento de Química , Universidade Federal de Santa Maria , 97105-900 Santa Maria , Rio Grande do Sul , Brazil.
出版信息
J Org Chem. 2019 Jul 19;84(14):8976-8983. doi: 10.1021/acs.joc.9b00867. Epub 2019 Jul 1.
PMID:31259554
Abstract
The synthetic potential of 5-bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one toward the catalyst-free synthesis of -pyrrolyl(furanyl)-piperazines, 1,4-diazepanes, and 1,4-diazocanes through a telescoped protocol is reported. This three-component one-pot method provided 23 examples with high chemo- and regioselectivity at yields up to 96%.
摘要
报告了 5-溴-1,1,1-三氟-4-甲氧基-3-戊烯-2-酮在无催化剂条件下通过缩合协议合成 -吡咯基（呋喃基）-哌嗪、1,4-二氮杂环庚烷和 1,4-二氮杂环辛烷的综合潜力。这种三组分一锅法提供了 23 个例子，具有高化学和区域选择性，产率高达 96%。
Zotero 插件