肾细胞癌中的易位t(3;8)(p14.2;q24.1)影响淋巴细胞中3p14（FRA3B）处常见脆性位点的表达。

Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes.

作者信息

Glover T W, Coyle-Morris J F, Li F P, Brown R S, Berger C S, Gemmill R M, Hecht F

机构信息

Genetics Center, Southwest Biomedical Research Institute, Scottsdale, AZ.

出版信息

Cancer Genet Cytogenet. 1988 Mar;31(1):69-73. doi: 10.1016/0165-4608(88)90013-1.

DOI:10.1016/0165-4608(88)90013-1

PMID:3125959

Abstract

The common fragile site at 3p14(FRA3B) is cytogenetically close to the positions of translocation and deletion breakpoints frequently observed in renal cell carcinoma (RCC) and small cell carcinoma of the lung. Possible involvement of this fragile site in the familial RCC t(3;8)(p14.2;q24.1) was investigated. Expression of FRA3B, induced by treatment of lymphocytes with aphidicolin, is altered by the translocation. These results suggest that the fragile site is very close to, if not coincident with, the translocation breakpoint.

摘要

位于3p14的常见脆性位点（FRA3B）在细胞遗传学上与肾细胞癌（RCC）和肺小细胞癌中频繁观察到的易位和缺失断点位置相近。研究了该脆性位点在家族性RCC t(3;8)(p14.2;q24.1)中的可能作用。用阿非迪霉素处理淋巴细胞诱导的FRA3B表达因易位而改变。这些结果表明，该脆性位点即使不与易位断点重合，也非常接近易位断点。