Kasbekar D K, Gordon G S
Am J Physiol. 1979 May;236(5):E550-5. doi: 10.1152/ajpendo.1979.236.5.E550.
The effects of colchicine and vinblastine on in vitro bullfrog gastric mucosal preparations were studied with respect to H+ and pepsinogen secretion. In the concentration range of 1--50 mM, an initial but transient colchicine-mediated stimulation of H+ secretion is followed by a dose-dependent inhibition. The transient stimulation of H+ secretion can be confirmed in resting preparations in the absence of added secretagogues. In the same concentration range, colchicine inhibits pepsinogen secretion to a greater degree than H+ secretion. Vinblastine (10(-5)--5 X 10(-4) M) was more effective than colchicine in inhibiting both H+ and pepsinogen secretion. The kinetics of inhibition of secretion by both colchicine and vinblastine were slow. Cytochalasin B had no effect on either secretion.
研究了秋水仙碱和长春碱对体外牛蛙胃黏膜制剂氢离子（H⁺）和胃蛋白酶原分泌的影响。在1 - 50 mM的浓度范围内，秋水仙碱最初会介导对H⁺分泌的短暂刺激，随后是剂量依赖性抑制。在没有添加促分泌剂的静息制剂中可以证实H⁺分泌的短暂刺激。在相同浓度范围内，秋水仙碱对胃蛋白酶原分泌的抑制程度大于对H⁺分泌的抑制。长春碱（10⁻⁵ - 5×10⁻⁴ M）在抑制H⁺和胃蛋白酶原分泌方面比秋水仙碱更有效。秋水仙碱和长春碱对分泌的抑制动力学都很缓慢。细胞松弛素B对两种分泌均无影响。
