Koparal Mahmut, Yalcın Eda Didem, Aksoy Orhan, Ozcan-Kucuk Ayse
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Adıyaman University, Merkez, 02200, Adıyaman, Turkey.
Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Gaziantep University, Sehitkamil, 27410, Gaziantep, Turkey.
Int J Pediatr Otorhinolaryngol. 2019 Oct;125:59-65. doi: 10.1016/j.ijporl.2019.06.022. Epub 2019 Jun 25.
Among children with β-thalassaemia, skeletal changes and abnormalities, such as decreased volume or obliteration of the sinus, result primarily from hypertrophy and expansion of the erythroid marrow due to ineffective erythropoiesis. This study evaluated the volumes and surface areas of the maxillary sinuses of children with β-thalassaemia using cone beam computed tomography (CBCT), and compared these findings with corresponding measurements in age- and sex-matched control children.
CBCT images were retrospectively evaluated for 16 children with β-thalassaemia, 19 children with a class I skeletal pattern (class I group), and 18 children with a class II skeletal pattern (class II group). After three-dimensional analyses and segmentation of each maxillary sinus, the volumes and surface areas were calculated.
The volumes and surface areas of the right (p > 0.05 and p > 0.05) and left maxillary sinuses (p > 0.05 and p > 0.05) and SNA angles (p > 0.05) were not significantly different among the groups. The ANB (p < 0.05) and SNGoMe (p < 0.05) angles were significantly greater and the SNB (p < 0.05) angle was significantly smaller in the class II and thalassaemia groups than in the class I group.
Children with thalassaemia tended to have lower maxillary sinus volumes and surface areas on both right and left sides, compared to those of children with class I and class II skeletal patterns; however, these differences were not statistically significant. In children with thalassaemia, a large intermaxillary discrepancy (ANB) indicated a tendency toward the class II skeletal pattern.
在β地中海贫血患儿中，骨骼变化及异常，如鼻窦容积减小或闭塞，主要是由于无效造血导致红系骨髓肥大和扩张所致。本研究使用锥形束计算机断层扫描（CBCT）评估β地中海贫血患儿上颌窦的容积和表面积，并将这些结果与年龄和性别匹配的对照儿童的相应测量值进行比较。
对16例β地中海贫血患儿、19例Ⅰ类骨骼型患儿（Ⅰ类组）和18例Ⅱ类骨骼型患儿（Ⅱ类组）的CBCT图像进行回顾性评估。在对每个上颌窦进行三维分析和分割后，计算其容积和表面积。
各组之间右侧（p>0.05和p>0.05）和左侧上颌窦的容积和表面积（p>0.05和p>0.05）以及SNA角（p>0.05）无显著差异。Ⅱ类组和地中海贫血组的ANB角（p<0.05）和SNGoMe角（p<0.05）显著大于Ⅰ类组，而SNB角（p<0.05）显著小于Ⅰ类组。
与Ⅰ类和Ⅱ类骨骼型患儿相比，地中海贫血患儿双侧上颌窦的容积和表面积往往较低；然而，这些差异无统计学意义。在地中海贫血患儿中，较大的颌间差异（ANB）表明有Ⅱ类骨骼型的倾向。
