脂肪来源干细胞来源的外泌体通过抑制 NF-κB 和 MAPK 通路缓解小胶质细胞激活引起的神经损伤。
Exosomes from adipose-derived stem cells alleviate neural injury caused by microglia activation via suppressing NF-kB and MAPK pathway.
机构信息
Medical research center, Beijing chaoyang hospital, Capital medical university, Beijing, China.
Medical research center, Beijing chaoyang hospital, Capital medical university, Beijing, China.
出版信息
J Neuroimmunol. 2019 Sep 15;334:576996. doi: 10.1016/j.jneuroim.2019.576996. Epub 2019 Jun 18.
Activation of microglia cells play critical role in neuroinflammation after brain injury. Exosomes from adipose-derived stem cells (ADSC) possess immunoregulation effect similar with ADSC. We hypothesized that ADSC derived exosomes (ADSC-exosomes) could inhibit the activation of microglia cells and prevent neuroinflammation. We found that ADSC-exosomes could inhibit the activation of microglia cells by suppressing NF-kB and MAPK pathway. Production of inflammatory factors in lipopolysaccharide-stimulated microglia cells decreased significantly when pretreated with ADSC-exosomes. Furthermore, ADSC-exosomes could decrease the cytotoxicity of activated microglia. These results revealed that ADSC-exosomes might be a promising strategy for the therapy of neural injury.
小胶质细胞的激活在脑损伤后的神经炎症中起着关键作用。脂肪来源的干细胞（ADSC）来源的外泌体具有与 ADSC 相似的免疫调节作用。我们假设 ADSC 衍生的外泌体（ADSC-exosomes）可以抑制小胶质细胞的激活，预防神经炎症。我们发现 ADSC-exosomes 可以通过抑制 NF-κB 和 MAPK 通路来抑制小胶质细胞的激活。用 ADSC-exosomes 预处理后，脂多糖刺激的小胶质细胞中炎症因子的产生显著减少。此外，ADSC-exosomes 可以降低激活的小胶质细胞的细胞毒性。这些结果表明，ADSC-exosomes 可能是治疗神经损伤的一种有前途的策略。
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