人乳腺癌病理学中的乳腺珠蛋白-A、血管内皮生长因子受体3和Ki67与五年生存率

Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival.

作者信息

Baker Elizabeth, Whiteoak Naomi, Hall Louise, France James, Wilson Deborah, Bhaskar Pudupalayam

机构信息

Department of Surgery, University Hospital of North Tees, Stockton on Tees, UK.

Department of Histopathology, University Hospital of North Tees, Stockton on Tees, UK.

出版信息

Breast Cancer (Auckl). 2019 Jun 26;13:1178223419858957. doi: 10.1177/1178223419858957. eCollection 2019.

BACKGROUND/METHODS: This study determines the co-expression of mammaglobin-A, vascular endothelial growth factor receptor-3 (VEGFR3) and Ki67 by immunohistochemistry (IHC) in tissue samples from 80 patients undergoing breast surgery (cancer or benign disease). The tissue expression was compared with the tumour histopathology and Kaplan Meier 5-year survival analysis was performed.

RESULTS

Positive breast tissue expression was observed in 53% samples for mammaglobin, 41% Ki67 and 65% VEGFR3 with a significant positive correlation between Ki67 and VEGFR3 co-expression. Ki67 and VEGFR3 expression correlated with the breast tumour grade and Ki67 expression also correlated with oestrogen receptor (ER) status. At 5 years post-operatively, 6/80 patients had died and 3 patients were alive but had cancer recurrence. High Ki67 expression significantly correlated with poor survival (disease-free and overall).

CONCLUSIONS

In this study, VEGFR3 and Ki67 expression but not mammaglobin-A correlated with breast tumour pathology. Positive Ki67 expression was also associated with a poor 5-year survival outcome.

背景/方法：本研究通过免疫组织化学（IHC）检测了80例接受乳房手术（癌症或良性疾病）患者的组织样本中乳腺珠蛋白-A、血管内皮生长因子受体-3（VEGFR3）和Ki67的共表达情况。将组织表达与肿瘤组织病理学进行比较，并进行Kaplan Meier 5年生存分析。

结果

乳腺珠蛋白在53%的样本中呈阳性表达，Ki67在41%的样本中呈阳性表达，VEGFR3在65%的样本中呈阳性表达，Ki67与VEGFR3的共表达之间存在显著正相关。Ki67和VEGFR3的表达与乳腺肿瘤分级相关，Ki67的表达也与雌激素受体（ER）状态相关。术后5年，80例患者中有6例死亡，3例存活但出现癌症复发。高Ki67表达与较差的生存率（无病生存率和总生存率）显著相关。