State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, No.17, 3rd Section of People's South Road, Chengdu 610041, China.
Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Biomed Res Int. 2019 May 27;2019:8609218. doi: 10.1155/2019/8609218. eCollection 2019.
Daptomycin (DAP), a cyclic lipopeptide produced by , is a novel antibiotic to clinically treat various Gram-positive pathogenic bacteria-induced infections. Although DAP has a strong broad-spectrum bactericidal effect, recently rare bacterial antibiotic resistance against DAP gradually arises. The review is to summarize the normal indications of DAP, its off-label usage against several clinical pathogen infections, the unique antibacterial mechanisms of DAP, and the combination of antibiotic therapies for highly DAP-resistant pathogens. More noticeably, rising evidences demonstrate that DAP has new potential activity of anticancer and immunomodulatory effects. So far the multifunctional pharmaceutical effects of DAP deserve to be further explored for future clinical applications.
达托霉素（DAP）是一种由 产生的环状脂肽，是一种新型抗生素，可临床治疗各种革兰氏阳性致病细菌引起的感染。尽管 DAP 具有强大的广谱杀菌作用，但最近罕见的细菌对 DAP 的耐药性逐渐出现。综述旨在总结 DAP 的常规适应症，其对几种临床病原体感染的超适应证使用，DAP 的独特抗菌机制，以及针对高度 DAP 耐药病原体的抗生素联合治疗。更值得注意的是，越来越多的证据表明 DAP 具有抗肿瘤和免疫调节作用的新潜在活性。到目前为止，DAP 的多功能药物作用值得进一步探索，以用于未来的临床应用。
