Spratt B G
Microbial Genetics Group, School of Biological Sciences, University of Sussex, Falmer, Brighton, UK.
Nature. 1988 Mar 10;332(6160):173-6. doi: 10.1038/332173a0.
Benzylpenicillin has been used extensively for approximately 40 years in the treatment of gonorrhoea. The intense selective pressures resulting from the continual exposure of Neisseria gonorrhoeae to penicillin have resulted in the emergence of resistant strains that produce altered forms of penicillin-binding proteins (PBPs) with decreased affinity for the antibiotic. A comparison of the sequences of the PBP-2 genes from penicillin-sensitive and penicillin-resistant strains, suggests that penicillin-resistant forms of PBP 2 may have arisen both by amino-acid substitutions and insertions, and by the exchange of a region encoding part of the penicillin-sensitive transpeptidase domain with the homologous region from a closely related species.
苄青霉素已广泛用于治疗淋病约40年。淋病奈瑟菌持续接触青霉素所产生的强大选择压力，导致了耐药菌株的出现，这些菌株产生了对该抗生素亲和力降低的青霉素结合蛋白（PBPs）改变形式。对青霉素敏感和耐药菌株的PBP-2基因序列进行比较表明，PBP 2的耐药形式可能通过氨基酸取代和插入以及通过与密切相关物种的同源区域交换编码部分青霉素敏感转肽酶结构域的区域而产生。
