Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, China.
Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, China.
Interdiscip Sci. 2019 Jun;11(2):300-306. doi: 10.1007/s12539-019-00333-y. Epub 2019 Jul 1.
Primary central nervous system lymphomas (PCNSLs) are rare progressive brain tumors, whose managements are significantly different from other solid tumors, especially glioblastomas. Therefore, an early diagnosis is of great significance. F-fluorodeoxyglucose (FDG)-positron emission tomography (PET), which can measure the glucose metabolic rate in the brain, is an increasingly common tool for early diagnosis. Twenty-five immunocompetent patients with PCNSL were reviewed in this study to describe the general characteristics of PCNSL patients' F-FDG-PET scans. Quantitative features included a radically enhanced maximum standardized uptake value (SUV) with a mean value of 23.8 ± 7.9 and a 5.8 ± 1.8 mean ratio of tumor-to-normal contralateral cortex activity (T/N). Visual characteristics, such as favored locations in the brain, lesion numbers, tumor shape, metabolic inhibition, and structural shift were determined as well. PCNSL was found to favor the cortex, especially the frontal lobe, followed by the basal ganglia and corpus callosum. All PCNSLs were near the lateral ventricular area. Tumor shapes were subdivided into three groups: diffuse, round, and irregular patterns. Reduced radiation was observed in the ipsilateral cortex, the basal ganglia and the contralateral cerebellum. The lateral ventricles were prone to be compressed on the side ipsilateral to the tumor, pushing the midline towards the contralateral side of the brain. In conclusion, aside from SUV and T/N values, other visual characteristics are also available to facilitate the differentiation of PCNSLs from other brain conditions on F-FDG-PET scans.
原发性中枢神经系统淋巴瘤（PCNSL）是一种罕见的进行性脑肿瘤，其治疗方法与其他实体瘤明显不同，尤其是胶质母细胞瘤。因此，早期诊断具有重要意义。氟-18 氟代脱氧葡萄糖（FDG）正电子发射断层扫描（PET）可测量大脑中的葡萄糖代谢率，是一种越来越常用的早期诊断工具。本研究回顾了 25 例免疫功能正常的 PCNSL 患者，以描述 PCNSL 患者 F-FDG-PET 扫描的一般特征。定量特征包括放射性增强的最大标准化摄取值（SUV），平均值为 23.8±7.9，肿瘤与对侧正常皮质活性（T/N）的平均比值为 5.8±1.8。还确定了视觉特征，如大脑中的优先位置、病变数量、肿瘤形状、代谢抑制和结构移位。PCNSL 倾向于位于皮质，特别是额叶，其次是基底节和胼胝体。所有 PCNSL 均靠近侧脑室区域。肿瘤形状分为三组：弥漫性、圆形和不规则形状。同侧皮质、基底节和对侧小脑放射性减少。肿瘤侧的侧脑室容易受压，将中线推向大脑对侧。总之，除了 SUV 和 T/N 值外，其他视觉特征也可用于在 F-FDG-PET 扫描中帮助区分 PCNSL 与其他脑部情况。
