Franzoni E, Mambelli M, Masoni P, Govoni M
Clinica Pediatrica I, Università degli Studi di Bologna, Italia.
Pediatr Med Chir. 1987 Sep-Oct;9(5):599-600.
We tested 187 blood samples to measure Primidone and Phenobarbital plasma levels. 63 were on monotherapy, whereas 124 on polytherapy. We founded a good relationship between PRI dosage and PB plasma levels. However, from our data, we can't find any correlation between PRI dosage and PRI level. Looking at correlations of polytherapy, BDZ and DPA do not change PRI and PB levels, whereas CBZ and DPH increase PB and decrease PRI, probably by inducing the biotransformation of the drug. In conclusion, we suggest the usefulness to measure together PRI and PB levels in order to obtain the best evaluation.
我们检测了187份血样以测定扑米酮和苯巴比妥的血浆水平。63例接受单一疗法，而124例接受联合疗法。我们发现扑米酮剂量与苯巴比妥血浆水平之间存在良好关系。然而，从我们的数据中，我们未发现扑米酮剂量与扑米酮水平之间存在任何相关性。观察联合疗法的相关性，苯二氮卓类药物和双丙戊酸不改变扑米酮和苯巴比妥水平，而卡马西平和苯妥英钠增加苯巴比妥水平并降低扑米酮水平，这可能是通过诱导药物的生物转化。总之，我们建议同时测定扑米酮和苯巴比妥水平以获得最佳评估。
