Massol J, Martin P, Brochet D, Puech A, Simon P
Département de Pharmacologie, Faculté de Médecine, Pitié-Salpêtrière, Paris, France.
Psychopharmacology (Berl). 1988;94(1):97-102. doi: 10.1007/BF00735888.
Triiodothyroacetic acid (TA3) is a natural thyroid analogue which possesses some of the properties of triiodothyronine (T3). In particular, it has an inhibitory effect on the thyreotropic axis, but its peripheral effects are reduced. Given the activity of T3 on psychopharmacological models of depression in rodents, we investigated the effects of TA3 on some pharmacological and behavioral tests in mice. TA3 antagonized apomorphine- and oxotremorine-induced hypothermia, potentiated yohimbine-induced toxicity and L-5-hydroxy-tryptophan-induced head twitches, but did not affect forced swimming-induced immobility or reserpine-induced hypothermia. Thus, TA3 was effective on the same psychopharmacological tests which have previously been used to demonstrate the antidepressant-like effects of T3. Moreover, TA3 under the same experimental conditions as T3 has little effect on the metabolic clearance rate parameters, and might, therefore, be preferable to T3 for clinical use in depression.
三碘甲状腺乙酸（TA3）是一种天然甲状腺类似物，具有一些三碘甲状腺原氨酸（T3）的特性。特别是，它对促甲状腺轴有抑制作用，但其外周作用减弱。鉴于T3对啮齿动物抑郁症心理药理学模型的活性，我们研究了TA3对小鼠一些药理学和行为学测试的影响。TA3拮抗阿扑吗啡和氧化震颤素诱导的体温过低，增强育亨宾诱导的毒性和L-5-羟色氨酸诱导的头部抽搐，但不影响强迫游泳诱导的不动或利血平诱导的体温过低。因此，TA3在先前用于证明T3抗抑郁样作用的相同心理药理学测试中有效。此外，在与T3相同的实验条件下，TA3对代谢清除率参数影响很小，因此，在抑郁症临床应用中可能比T3更可取。
