Vaccari A
Eur J Pharmacol. 1982 Aug 13;82(1-2):93-5. doi: 10.1016/0014-2999(82)90559-3.
Male rats born of mothers kept on an iodide-free diet from day 15 of pregnancy up to day 4 post-delivery, were rendered hypothyroid by a daily s.c. injection of methimazole, 20-25 mg/kg from day 1 up to day 30 of age. Two days after the last injection, euthyroid and hypothyroid rats were given 220 mg/kg i.p. of L-5-hydroxytryptophan (5-HTP). The resulting behavioral syndrome was much less intense in hypothyroids, compared to euthyroids, thus suggesting a state of serotonergic hypoactivity.
从怀孕第15天到产后第4天，母鼠持续食用无碘饮食，所生的雄性大鼠从出生第1天到30日龄，每天皮下注射20 - 25毫克/千克甲巯咪唑，使其甲状腺功能减退。在最后一次注射两天后，对甲状腺功能正常和甲状腺功能减退的大鼠腹腔注射220毫克/千克的L - 5 - 羟色氨酸（5 - HTP）。与甲状腺功能正常的大鼠相比，甲状腺功能减退的大鼠所产生的行为综合征强度要低得多，这表明存在血清素能活动减退的状态。
