Kinnunen O, Salokannel J
Department of Medicine, Health Centre Hospital of Oulu, Finland.
Ann Clin Res. 1987;19(5):321-3.
Sixty-four geriatric long-stay patients aged 65 years or older participated in the trial. All were using laxatives prior to the study. For the study laxatives the mean dose of magnesium hydroxide was 25 ml daily and for bulk-laxative 8.7 g daily. Magnesium hydroxide caused a more frequent bowel habit (13.2 vs. 10.4/4 weeks, p less than 0.001) than bulk-laxative and additional laxative bisacodyl was not needed as often as with bulk-laxative (2.3 vs. 3.3/4 weeks, p less than 0.01). Also the stool consistency was more normal during the magnesium hydroxide treatment. In two patients serum magnesium was over 1.25 mmol/l after the magnesium hydroxide treatment but there were no clinical signs of hypermagnaesemia. Our study indicated magnesium hydroxide to be more efficient than bulk-laxative in treating constipation in elderly long-stay patients.
64名65岁及以上的老年长期住院患者参与了该试验。所有患者在研究前均使用泻药。研究中，氢氧化镁的平均剂量为每日25毫升，容积性泻药为每日8.7克。与容积性泻药相比，氢氧化镁导致排便习惯更频繁（13.2次/4周对10.4次/4周，p<0.001），且与容积性泻药相比，额外使用缓泻药比沙可啶的频率更低（2.3次/4周对3.3次/4周，p<0.01）。此外，在氢氧化镁治疗期间，大便质地更正常。两名患者在氢氧化镁治疗后血清镁超过1.25 mmol/L，但无高镁血症的临床体征。我们的研究表明，在治疗老年长期住院患者便秘方面，氢氧化镁比容积性泻药更有效。
