Ploegmakers H H, Mertens M J, van Oort W J
Department of Analytical Pharmacy, Faculty of Pharmacy, State University of Utrecht, The Netherlands.
Anticancer Res. 1987 Nov-Dec;7(6):1315-9.
In high performance liquid chromatography with electrochemical detection (HPLC/ECD) much attention has been paid to the performance of the applied detection system with respect to reliability and sensitivity. In general, insufficient attention has been paid to relatively easy to implant devices for improved collection and handling of detection signals. Four models of software filtering are studied and compared with hardware filtering. In the investigated chromatographic-electrochemical system, off-line parabolic filtering after on-line averaging of sixteen measurements proved to be the system of first choice, with respect to execution time, noise level, signal to noise ratio, peak height and resolution.
在高效液相色谱电化学检测法（HPLC/ECD）中，人们非常关注所应用检测系统在可靠性和灵敏度方面的性能。总体而言，对于相对易于植入的用于改进检测信号采集和处理的装置，关注不足。研究了四种软件滤波模型，并与硬件滤波进行了比较。在所研究的色谱 - 电化学系统中，就执行时间、噪声水平、信噪比、峰高和分辨率而言，在对十六次测量进行在线平均后进行离线抛物线滤波被证明是首选系统。
