Lobo Cheryl A, Cursino-Santos Jeny R, Singh Manpreet, Rodriguez Marilis
Department of Blood Borne Parasites, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 100065, USA.
Pathogens. 2019 Jul 2;8(3):95. doi: 10.3390/pathogens8030095.
is an obligate intracellular protozoan parasite that causes zoonotic disease. Central to its pathogenesis is the ability of the parasite to invade host red blood cells of diverse species, and, once in the host blood stream, to manipulate the composition of its population to allow it to endure unfavorable conditions. Here we will review key in vitro studies relating to the survival strategies that adopts during its intraerythrocytic development to persist and how proliferation is restored in the parasite population once optimum conditions return.
是一种专性细胞内原生动物寄生虫,可引起人畜共患病。其发病机制的核心在于该寄生虫侵入不同物种宿主红细胞的能力,并且一旦进入宿主血流,能够操纵其群体组成以使其能够耐受不利条件。在此,我们将回顾与该寄生虫在红细胞内发育过程中为持续存在而采取的生存策略相关的关键体外研究,以及一旦最佳条件恢复,寄生虫群体中增殖是如何恢复的。