癌症化疗治疗的儿科患者的体温和血细胞计数，NCT01683370。
Temperatures and blood counts in pediatric patients treated with chemotherapy for cancer, NCT01683370.
机构信息
Division of Pediatric Hematology/Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Division of Oncology, Medical Services of the Statutory Health Insurance Baden-Württemberg, Tübingen, Germany.
出版信息
Sci Data. 2019 Jul 3;6(1):108. doi: 10.1038/s41597-019-0112-8.
Fever in neutropenia (FN) is the most frequent potentially lethal complication of chemotherapy in patients with cancer. The temperature limit defining fever (TLDF) for FN is based on scarce evidence. This prospective, single center observational study recruited non-selected pediatric patients diagnosed with cancer between ≥1 and ≤17 years in 2012 and 2013. Of 40 patients potentially eligible, 39 participated. Data of 8896 temperature measurements and 1873 complete blood counts (CBCs) were recorded over 289 months (24.1 years) of chemotherapy exposure time. During this time 43 FN episodes were diagnosed. In 32 episodes, FN diagnosis was based on reaching the local (i.e. Bern, Switzerland) standard TLDF of 39.0 °C; another 11 episodes had been captured by clinical judgement (i.e. temperature < 39.0 °C). These data can be used to simulate the effects of various TLDFs on the rate of FN diagnosis. We assume merging these data with other data sets is feasible.
中性粒细胞减少症（FN）发热是癌症患者化疗中最常见的潜在致命并发症。FN 发热的温度限定值（TLDF）是基于有限的证据。本前瞻性、单中心观察性研究于 2012 年至 2013 年招募了≥1 至≤17 岁被诊断患有癌症的非选择性儿科患者。在 40 名潜在合格的患者中，有 39 名患者参与了研究。在 289 个月（24.1 年）的化疗暴露时间内，记录了 8896 次体温测量和 1873 次完整的血细胞计数（CBC）的数据。在此期间，诊断出 43 例 FN 发作。在 32 个病例中，FN 的诊断是基于达到当地（即瑞士伯尔尼）的标准 TLDF 39.0°C；另有 11 个病例是基于临床判断（即体温<39.0°C）。这些数据可用于模拟各种 TLDF 对 FN 诊断率的影响。我们假设将这些数据与其他数据集合并是可行的。
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