成人结核性脑膜炎、病毒性脑膜炎和细菌性脑膜炎鉴别统一病例定义标准的验证
Validation of the Uniform Case Definition Criteria for Differentiating Tuberculous Meningitis, Viral Meningitis, and Bacterial Meningitis in Adults.
作者信息
Kim Min Chul, Park Ki Ho, Lee Sang Ahm, Kim Sung Han
机构信息
Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea.
Division of Infectious Diseases, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea.
出版信息
Infect Chemother. 2019 Jun;51(2):188-190. doi: 10.3947/ic.2019.51.2.188.
We validated the uniform case definition for differentiating tuberculous meningitis (TBM) from both viral meningitis (VM) and bacterial meningitis (BM) in adults from South Korea, a country with an intermediate TB-burden. 'Probable' TBM differentiated 'definite' TBM with a sensitivity of 81% and specificity of 98%. 'Possible TBM' criteria identified 'definite' TBM with a sensitivity of 100% and specificity of 60%. Despite the usefulness of the uniform case definition criteria, there was substantial overlaps among VM, BM, and 'possible' TBM, especially in severe cases of VM and indolent cases of BM.
我们验证了统一的病例定义，用于区分韩国成年人群中结核性脑膜炎（TBM）与病毒性脑膜炎（VM）和细菌性脑膜炎（BM），韩国是一个结核病负担中等的国家。“疑似”TBM与“确诊”TBM的区分中，敏感性为81%，特异性为98%。“可能的TBM”标准识别“确诊”TBM的敏感性为100%，特异性为60%。尽管统一病例定义标准有用，但VM、BM和“可能的”TBM之间存在大量重叠，尤其是在VM的严重病例和BM的隐匿性病例中。
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