Smith W J, Garson J A, Bourne S P, Kemshead J T, Coakham H B
Department of Histopathology, University College Medical School, Bristol.
J Clin Pathol. 1988 Feb;41(2):128-32. doi: 10.1136/jcp.41.2.128.
Six cases of primary cerebral lymphoma were immunophenotyped and analysed by Southern blotting to determine the clonality and lineage of these neoplasms. Molecular analysis showed that they were of B cell origin, and the rearrangement of both heavy and light chain immunoglobulins in malignant cells showed that they were monoclonal populations of mature B cells. The characterisation of the genetic configuration of the immunoglobulin genes in these lymphomas is important because the ability to distinguish between primary lymphoma of the central nervous system and other malignant cerebral tumours has important implications for treatment and survival.
对6例原发性脑淋巴瘤进行免疫表型分析,并通过Southern印迹法进行分析,以确定这些肿瘤的克隆性和谱系。分子分析表明它们起源于B细胞,恶性细胞中重链和轻链免疫球蛋白的重排表明它们是成熟B细胞的单克隆群体。这些淋巴瘤中免疫球蛋白基因遗传构型的特征很重要,因为区分中枢神经系统原发性淋巴瘤和其他恶性脑肿瘤的能力对治疗和生存具有重要意义。