一名T细胞恶性淋巴瘤患者中免疫球蛋白重链基因重排及T3表达，而T细胞受体β链基因无重排

Rearrangement of immunoglobulin heavy chain genes and T3 expression in the absence of rearrangement of T-cell receptor beta-chain gene in a patient with T-cell malignant lymphoma.

作者信息

Ogawa H, Sugiyama H, Oka Y, Maeda T, Komori T, Tani Y, Miyake S, Soma T, Maekura R, Yutani C

出版信息

Leuk Res. 1986;10(12):1369-75. doi: 10.1016/0145-2126(86)90002-0.

Abstract

We describe the rearrangement of immunoglobulin genes and T3 expression in the absence of rearrangement of T-cell receptor beta-chain genes in a patient with T-cell malignant lymphoma. He had a mediastinal mass and his lymphoma cells expressed T-cell antigens (OKT3+, OKT9+, and OKT10+). When we examined genomic DNA from the lymphoma cells, we detected the rearrangement of immunoglobulin heavy chain genes with a germ-line configuration of light chain genes and no rearrangement of T-cell receptor beta-chain gene. These results indicated that the rearrangement of immunoglobulin genes could occur in T-cell malignant lymphoma, and that T3 antigen could be expressed prior to the rearrangement of T-cell receptor beta-chain genes under certain circumstances.

摘要

我们描述了一名T细胞恶性淋巴瘤患者在T细胞受体β链基因未发生重排的情况下免疫球蛋白基因的重排及T3表达情况。他有纵隔肿块，其淋巴瘤细胞表达T细胞抗原（OKT3 +、OKT9 +和OKT10 +）。当我们检测淋巴瘤细胞的基因组DNA时，我们检测到免疫球蛋白重链基因发生重排，轻链基因呈种系构型，且T细胞受体β链基因未发生重排。这些结果表明免疫球蛋白基因重排可发生于T细胞恶性淋巴瘤，并且在某些情况下T3抗原可在T细胞受体β链基因重排之前表达。