Evaluation of Antibacterial Effect against and Biocompatibility of Essential Oil Extracted from the Gum of .

OBJECTIVE

This study investigates the antibacterial effect of essential oil extracted from the gum of against and histological evaluation of an experimental gel of the extract in wound healing in the back subcutaneous tissue of Wistar rats.

METHODS

Clinical strains of bacteria obtained from subgingival plaque samples of individuals having periodontitis, isolation, and confirmation were done by conventional microbiological tests and molecular technique. Essential oil was extracted by using hydrodistillation method; antibacterial activity has been determined by two fold serial dilution method. Histological evaluation conducted on fifteen Wistar rats. Incisions were made on the dorsal surface of each animal for implanting of 3 polysilicone tubes (empty, tetracycline gel, and the experimental gel). After 1, 4, and 8 weeks, the animals were euthanized and the specimens were prepared histologically.

RESULT

The extract demonstrated antimicrobial effect and significant wound healing in the different study durations particularly our product showed progression in epidermal wound healing and decrease in cellularity and scoring of inflammatory cells.

CONCLUSION

The extract was able to pose inhibitory and bactericidal activity against and the experimental gel was able to have a good wound healing that enable it to be considered as a compatible material.