Taylor D M
AFRC & MRC Neuropathogenesis Unit, Edinburgh, United Kingdom.
Lab Anim. 1988 Jan;22(1):27-34. doi: 10.1258/002367788780746557.
Proteus mirabilis was the predominant cause of acute diabetes-associated pyelonephritis occurring spontaneously in male MM mice until they were segregated in a new environment. Thereafter Pasteurella pneumotropica and Streptococcus faecalis emerged collectively as the most common causal organisms, the pyelonephritis became more chronic and Proteus mirabilis isolates from faeces and urine produced atypical non-swarming colonies on blood agar plates. This did not account for the reduced pathogenicity of Proteus mirabilis; when MM males were returned to the original environment the pyelonephritis again became acute but was associated with the atypical type of Proteus mirabilis although the normal type was abundant in the environment. The MM mice were Caesarean-derived and cross-fostered shortly before their transfer to the second environment, which probably accounts for their changed microbial status, but the reason for the emergence of the atypical type of Proteus mirabilis is not understood. The acute nature of the male MM pyelonephritis when caused by Proteus mirabilis parallels the situation described in other animals and humans.
奇异变形杆菌是雄性MM小鼠自发性急性糖尿病相关性肾盂肾炎的主要病因，直到它们被安置在新环境中。此后，嗜肺巴斯德杆菌和粪肠球菌共同成为最常见的致病生物，肾盂肾炎变得更加慢性，从粪便和尿液中分离出的奇异变形杆菌在血琼脂平板上产生非典型的不扩散菌落。这并不能解释奇异变形杆菌致病性的降低；当雄性MM小鼠回到原来的环境中时，肾盂肾炎再次变为急性，但与奇异变形杆菌的非典型类型有关，尽管正常类型在环境中大量存在。MM小鼠是剖腹产出生的，并在转移到第二个环境之前不久进行了交叉寄养，这可能解释了它们微生物状态的变化，但奇异变形杆菌非典型类型出现的原因尚不清楚。由奇异变形杆菌引起的雄性MM肾盂肾炎的急性性质与其他动物和人类中描述的情况相似。
