Military Pharmacy "Slavija", Central Pharmacy-Storage, Department for Military Health, 11000 Belgrade, Serbia.
Department of Pharmacy, Military Medical Academy, 11000 Belgrade, Serbia.
Medicina (Kaunas). 2019 Jul 3;55(7):332. doi: 10.3390/medicina55070332.
The purpose of the study was to determine the prevalence rate of potentially inappropriate prescribing (PIP), by using the Screening Tool of Older Person's potentially inappropriate Prescriptions (STOPP) criteria in older outpatients, and its association with potential clinically significant drug-drug interactions (csDDIs). A cross-sectional study included 248 outpatients ≥65 years old divided into two groups depending on the presence of csDDIs. For estimating the clinical significance of csDDIs we used Medscape's "Drug Interaction Checker". We applied the thirty PIP indicators from the STOPP criteria. The presence of PIP (25.00%; all patients) was significantly higher in the group with potential csDDIs compared to the other group (43 vs. 19, respectively; Chi-square test, χ = 9.947; < 0.01). The most common PIP included the inappropriate use of proton pump inhibitors, long acting benzodiazepines, usage of thiazide diuretic in patients with gout, and duplication of therapeutic class. Patients with potential csDDIs had 43 potentially inappropriate medications (PIMs) prescribed. Out of this number, 12 (27.91%) PIMs were identified to participate in potential csDDIs. There was a correlation between the number of medications prescribed and the number of PIMs (ρ = 0.297; < 0.01) and between the number of PIPs and the number of potential csDDIs (ρ = 0.170; < 0.01). Older outpatients with potential csDDIs in relation to those with no potential csDDIs had significantly more prescribed drugs in total as well as inappropriate drugs. Almost 30% of these PIMs were included in potential csDDIs.
本研究旨在通过使用老年人潜在不适当处方筛选工具（STOPP）标准确定老年门诊患者潜在不适当处方（PIP）的流行率，并研究其与潜在临床显著药物相互作用（csDDIs）的相关性。一项横断面研究纳入了 248 名年龄≥65 岁的门诊患者，根据是否存在 csDDIs 将其分为两组。为了评估 csDDIs 的临床意义，我们使用了 Medscape 的“药物相互作用检查器”。我们应用了 STOPP 标准的 30 个 PIP 指标。与无潜在 csDDIs 的组相比，有潜在 csDDIs 的组中 PIP（25.00%；所有患者）的发生率明显更高（分别为 43 例和 19 例；卡方检验，χ=9.947；<0.01）。最常见的 PIP 包括质子泵抑制剂、长效苯二氮䓬类药物、痛风患者使用噻嗪类利尿剂以及治疗类别重复使用的不合理用药。有潜在 csDDIs 的患者共开具了 43 种潜在不适当药物（PIMs）。其中 12 种（27.91%）PIMs被确定为潜在 csDDIs。开具的药物数量与 PIMs 的数量之间存在相关性（ρ=0.297；<0.01），与 PIPs 的数量与潜在 csDDIs 的数量之间也存在相关性（ρ=0.170；<0.01）。与无潜在 csDDIs 的患者相比，有潜在 csDDIs 的老年门诊患者的总用药量和不合理用药量均显著增加。这些 PIMs 中有近 30%被纳入潜在 csDDIs。
