Pierorazio Phillip Martin, Biles Michael Janney
Department of Urology, Brady Urological Institute, Johns Hopkins Hospital, 600 North Wolfe Street, Park 217, Baltimore, MD 21287-0005, USA.
Department of Urology, Brady Urological Institute, Johns Hopkins Hospital, 600 North Wolfe Street, Park 217, Baltimore, MD 21287-0005, USA.
Urol Clin North Am. 2019 Aug;46(3):399-407. doi: 10.1016/j.ucl.2019.04.005. Epub 2019 May 21.
Seminoma is commonly diagnosed in young men, and it has therefore become a disease of long-term survivors. As the late toxic effects of radiation and chemotherapy are better understood, it is becoming imperative to focus management advancements on reducing exposure to toxic agents. Retroperitoneal lymph node dissection (RPLND) currently is indicated as a salvage procedure in postchemotherapy patients with residual masses. Primary RPLND currently is being further explored in patients with clinical stage IA and clinical stage IB disease in 2 prospective studies.
精原细胞瘤常见于年轻男性，因此它已成为一种长期生存者的疾病。随着对放疗和化疗晚期毒性作用的深入了解，将管理进展重点放在减少接触毒性药物上变得势在必行。目前，腹膜后淋巴结清扫术（RPLND）被用作化疗后有残留肿块患者的挽救性手术。在两项前瞻性研究中，目前正在对临床分期IA和临床分期IB疾病的患者进一步探索原发性RPLND。
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