巴基斯坦海得拉巴人群维生素D缺乏及其影响因素的研究。

Study of Vitamin D deficiency and contributing factors in the population of Hyderabad, Pakistan.

作者信息

Kandhro Farhatullah, Dahot Umar, Naqvi Syed Habib Ahmed, Ujjan Ikram Uddin

机构信息

Institute of Biotechnology and Genetic Engineering, university of Sindh, Jamshoro, Pakistan, 1Isra University Hospital, Hyderabad, Pakistan.

出版信息

Pak J Pharm Sci. 2019 May;32(3):1063-1068.

PMID:31278721

Abstract

The study of vitamin D (25-OHD) deficiency was intended to analyse the incidence and some contributing factors amid healthy individuals of different living standards in general population of Hyderabad and its adjacent areas. A total of 1244 healthy individuals (1-84 year of age) (females 725 (58.2%) and males 519 (41.8%)) were selected in this study and the concentration of Serum vitamin D (25-OHD), phosphorus, alkaline phosphatase and calcium was analysed. The prevalence of vitamin D (25-OHD) deficiency was 78.3%. The values <10ng/mL were noted as severe deficiency, 10-20ng/ml moderate and 21-29.9ng/ml as mild deficiency or insufficiency. The degrees of vitamin D (25-OHD) deficiency amongst the healthy individuals were severe (17.2%), mild (18.8%) and moderate (42.3%). Vitamin D (25-OHD) was positively correlated with blood calcium profile whereas alkaline phosphatase and phosphorus correlated negatively. The study showed that vitamin D (25-OHD) deficiency has a high prevalence in healthy subjects.

摘要

对维生素D（25-羟基维生素D）缺乏症的研究旨在分析海得拉巴及其邻近地区普通人群中不同生活水平的健康个体的发病率及一些影响因素。本研究共选取了1244名健康个体（年龄在1至84岁之间）（女性725名（58.2%），男性519名（41.8%）），并对血清维生素D（25-羟基维生素D）、磷、碱性磷酸酶和钙的浓度进行了分析。维生素D（25-羟基维生素D）缺乏症的患病率为78.3%。维生素D水平<10ng/mL被视为严重缺乏，10-20ng/mL为中度缺乏，21-29.9ng/mL为轻度缺乏或不足。健康个体中维生素D（25-羟基维生素D）缺乏的程度为严重（17.2%）、轻度（18.8%）和中度（42.3%）。维生素D（25-羟基维生素D）与血钙水平呈正相关，而碱性磷酸酶和磷与之呈负相关。该研究表明，维生素D（25-羟基维生素D）缺乏症在健康受试者中具有较高的患病率。