Amin Sima, Jamerson Jordan, Tee Ronald G, Parekh Palak
Texas A&M Health Sciences Center, College Station, Texas.
Department of Dermatology, Baylor Scott & White, Temple, Texas.
J Cutan Pathol. 2019 Dec;46(12):945-948. doi: 10.1111/cup.13542. Epub 2019 Jul 22.
Histiocytoses are a group of rare disorders characterized by a proliferation of monocytes/macrophages and dendritic cells. We present a case of a 3-year-old girl with a diffuse papular eruption without systemic symptoms demonstrating a proliferation of strongly CD1a histiocytes, but negative for S-100 and langerin on histopathology. Systemic work-up including bone marrow biopsy was unremarkable, and the patient received a diagnosis of CD1a S 100-indeterminate cell histiocytosis.
组织细胞增多症是一组罕见的疾病，其特征为单核细胞/巨噬细胞和树突状细胞增殖。我们报告一例3岁女童，其有弥漫性丘疹疹且无全身症状，组织病理学显示CD1a强阳性组织细胞增殖，但S-100和朗格蛋白呈阴性。包括骨髓活检在内的全身检查无异常，该患者被诊断为CD1a S 100不确定细胞组织细胞增多症。
