Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing 100037, China; Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing 100037, China.
Prostaglandins Other Lipid Mediat. 2019 Oct;144:106345. doi: 10.1016/j.prostaglandins.2019.106345. Epub 2019 Jul 3.
BACKGROUND: Oxidized-low-density lipoprotein (ox-LDL), as well as high-density lipoprotein (HDL) and its subfractions play important role in the development of coronary artery disease (CAD). METHODS: A total of 1417 individuals who received selective coronary angiography (CAG) without lipids-lowering treatments were consecutively enrolled. Patients were divided into CAD (n = 942) and non-CAD group (n = 475). The severity of CAD was assessed by Gensini Scores (GS) system. The correlations of ox-LDL with HDL subfractions were analyzed. RESULTS: Compared with non-CAD subjects, CAD patients had higher ox-LDL but lower concentrations of HDL cholesterol (p = 0.002) and large HDL subfractions (p = 0.004). And ox-LDL was negatively correlated with large HDL subfractions in patients with severe CAD (p < 0.05). Moreover, ox-LDL was elevated and large HDL subfractions decreased with the increase of the number of stenotic coronary arteries and GS (p < 0.05, respectivelly). CONCLUSIONS: The correlations between ox-LDL and cholesterol level of large HDL particles varied among CAD and non-CAD, and CAD with different severities of atherosclerosis.
背景：氧化型低密度脂蛋白（ox-LDL）以及高密度脂蛋白（HDL）及其亚组份在冠状动脉疾病（CAD）的发生发展中起重要作用。
方法：连续纳入了 1417 名未接受降脂治疗而行选择性冠状动脉造影（CAG）的患者。将患者分为 CAD 组（n=942）和非 CAD 组（n=475）。采用 Gensini 评分（GS）系统评估 CAD 的严重程度。分析 ox-LDL 与 HDL 亚组份的相关性。
结果：与非 CAD 患者相比，CAD 患者的 ox-LDL 水平较高，但高密度脂蛋白胆固醇（p=0.002）和大 HDL 亚组份的浓度较低（p=0.004）。在严重 CAD 患者中，ox-LDL 与大 HDL 亚组份呈负相关（p<0.05）。此外，ox-LDL 水平升高，大 HDL 亚组份减少，与狭窄冠状动脉数量和 GS 的增加呈正相关（p<0.05，分别）。
结论：ox-LDL 与大 HDL 颗粒胆固醇水平的相关性在 CAD 和非 CAD 以及不同严重程度动脉粥样硬化的 CAD 患者中有所不同。
Prostaglandins Other Lipid Mediat. 2019-7-3
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