Division of Infection, Immunity, and Respiratory Medicine, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom; Division of Infection, Immunity, and Respiratory Medicine, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Division of Infection, Immunity, and Respiratory Medicine, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom; Department of Respiratory Medicine, North Manchester General Hospital, Pennine Acute NHS Trust, Manchester, United Kingdom.
J Allergy Clin Immunol Pract. 2019 Jul-Aug;7(6):1731-1738. doi: 10.1016/j.jaip.2019.04.027.
Chronic coughing has a significant impact on the sufferer's quality of life. Despite this, licensed therapies are currently lacking, and until recently novel efficacious therapies for the treatment of chronic cough have remained elusive. In recent years, a first in class P2X3 antagonist has been found to be efficacious in patients with refractory chronic cough, stimulating much interest in the development of therapies for this problem. The aim of this review is to summarize the current state of development of novel therapies acting both in the peripheral and central nervous systems. Most programs are focused on treating patients with refractory chronic cough, but chronic coughing is also a problem in common respiratory diseases in spite of standard care. However, unraveling of the pathophysiological mechanisms underlying cough will ultimately be needed to identify the relevant drug targets, better characterize patients, and match them to the most appropriate treatments.
慢性咳嗽会显著影响患者的生活质量。尽管如此，目前仍然缺乏许可的治疗方法，直到最近，治疗慢性咳嗽的新型有效疗法仍然难以捉摸。近年来，人们发现一种新型的 P2X3 拮抗剂对难治性慢性咳嗽患者有效，这激发了人们对开发这种疾病治疗方法的极大兴趣。本综述的目的是总结目前作用于外周和中枢神经系统的新型治疗方法的发展状况。大多数项目都集中在治疗难治性慢性咳嗽的患者上，但慢性咳嗽也是常见呼吸道疾病的一个问题，尽管有标准的治疗方法。然而，为了确定相关的药物靶点，更好地描述患者特征，并将他们与最合适的治疗方法相匹配，最终需要阐明咳嗽的病理生理机制。
