Department of Surgery, University of Colorado, Aurora, Colorado.
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
Breast J. 2019 Nov;25(6):1111-1116. doi: 10.1111/tbj.13429. Epub 2019 Jul 6.
Patients undergoing the addition of a contralateral prophylactic mastectomy with unilateral breast cancer have an increased and potentially doubled post-operative complication rate. One documented detriment from post-operative complications is the potential delay in initiating adjuvant therapy. To determine if the addition of a gynecologic and/or plastic reconstructive procedure to breast surgery results in an increased risk of postoperative complications and re-admissions, we evaluated outcomes in patients undergoing single vs multi-site surgery in a large national surgical database. We utilized the National Surgery Quality Improvement Program (NSQIP) database to identify patients who underwent breast surgery between 2011 and 2015. We extracted patients who underwent prophylactic oophorectomy with or without hysterectomy as a comparison group. Chi square analysis was used to assess postoperative outcomes including complications, readmission, and reoperation. All statistics were performed in SPSS v. 24. During the study timeframe, 77 030 patients had a solitary or combined breast surgical procedure and a second cohort of 124 patients underwent gynecologic surgery. Breast cancer patients who did not have a simultaneous reconstruction or gynecologic procedure were older with more comorbidities. Patients undergoing coordinated procedures had a significantly longer length of stay, higher complication, readmission, and reoperation rates (P < 0.001 for all) as compared with patients who underwent single site surgery. Patients with surgery for breast cancer, either with a plastic or gynecologic procedure, have greater postoperative complications. Higher complication rates for those with coordinated operations may lead to delays in adjuvant therapy and discussions regarding the indications for simultaneous surgery are recommended.
接受单侧乳腺癌同期对侧预防性乳房切除术的患者术后并发症发生率增加,且潜在风险翻倍。术后并发症的一个明显不良影响是辅助治疗的潜在延迟。为了确定在乳房手术中增加妇科和/或整形重建手术是否会增加术后并发症和再入院的风险,我们在一个大型国家外科数据库中评估了单部位手术与多部位手术患者的结局。我们利用国家手术质量改进计划(NSQIP)数据库,确定了 2011 年至 2015 年间接受乳房手术的患者。我们提取了同时或不同时接受预防性卵巢切除术和/或子宫切除术的患者作为对照组。卡方分析用于评估术后结局,包括并发症、再入院和再次手术。所有统计均在 SPSS v. 24 中进行。在研究期间,77030 名患者进行了单纯或联合乳房手术,另有 124 名患者进行了妇科手术。未同时进行重建或妇科手术的乳腺癌患者年龄较大,合并症更多。接受联合手术的患者住院时间更长,并发症、再入院和再次手术的发生率更高(所有 P 值均<0.001)。与单部位手术患者相比,行乳房癌手术的患者(伴或不伴整形手术)的术后并发症更多。对于联合手术的患者,更高的并发症发生率可能导致辅助治疗延迟,建议对同时手术的适应证进行讨论。