Department of Endocrinology and Metabolism, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Department of Endocrinology and Metabolism, Odense University Hospital, University of Southern Denmark, Odense, Denmark; Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark.
Fertil Steril. 2019 Oct;112(4):764-772. doi: 10.1016/j.fertnstert.2019.05.013. Epub 2019 Jul 4.
To determine predictors of maternal serum (S) and urinary (U) cortisol and cortisone levels during the third trimester and to examine associations between maternal cortisol status, offspring sex, and maternal polycystic ovary syndrome (PCOS) status.
Prospective observational study.
The study is part of the prospective Odense Child Cohort.
PATIENT(S): The study cohort included 1,489 women (with PCOS, n = 145; without PCOS, n = 1,344).
INTERVENTION(S): Fasting blood samples, 24-hour urinary samples.
MAIN OUTCOME MEASURE(S): Fasting morning S-cortisol and 24-hour U-cortisol/U-cortisone (24-hour U-C/C) were collected at gestational week 28 and measured by liquid chromatography-tandem mass spectrometry.
RESULT(S): Maternal S-cortisol levels were significantly higher in women pregnant with girls (n = 702) vs. boys (n = 787): mean (mean - SD; mean + SD) 833 (643; 1,079) vs. 799 (588; 1,083) nmol/L. In multiple regression analyses, maternal S-cortisol was positively associated with female offspring and inversely associated with maternal age and parity. When women were divided according to PCOS status, 24-hour U-cortisone was higher: 467 (334; 652) vs. 415 (286; 604) nmol/24 hours; and 24-hour U-C/C was lower in women with PCOS compared with women without PCOS.
CONCLUSION(S): Maternal third trimester S-cortisol levels were positively associated with female offspring. Cortisol metabolism was higher in women with PCOS vs. women without PCOS.
确定母体血清（S）和尿液（U）皮质醇和皮质酮水平在第三孕期的预测因素，并研究母体皮质醇状态、后代性别和母体多囊卵巢综合征（PCOS）状态之间的关联。
前瞻性观察研究。
该研究是前瞻性奥登塞儿童队列的一部分。
研究队列包括 1489 名女性（PCOS 组，n=145；非 PCOS 组，n=1344）。
空腹血样、24 小时尿样。
在妊娠 28 周时采集空腹晨 S-皮质醇和 24 小时 U-皮质醇/U-皮质酮（24 小时 U-C/C），并通过液相色谱-串联质谱法进行测量。
怀女孩（n=702）的女性母体 S-皮质醇水平明显高于怀男孩（n=787）的女性：平均值（平均值-标准差；平均值+标准差）833（643；1079）vs. 799（588；1083）nmol/L。在多元回归分析中，母体 S-皮质醇与女性后代呈正相关，与母体年龄和产次呈负相关。当根据 PCOS 状态将女性分组时，24 小时 U-皮质酮更高：467（334；652）vs. 415（286；604）nmol/24 小时；与无 PCOS 的女性相比，PCOS 女性的 24 小时 U-C/C 较低。
母体第三孕期 S-皮质醇水平与女性后代呈正相关。与无 PCOS 的女性相比，PCOS 女性的皮质醇代谢更高。
