Yamamoto M, Saitoh Y, Ohyanagi H, Ishida T, Shimada Y, Tagashira Y, Fujimoto T, Kurogoh F, Okumura S, Uchida K
Dept. of Surgery, Kobe University Hospital.
Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 1):703-7.
The effect of chemotherapy in the treatment of pancreatic cancer was evaluated on the basis of prognosis in 299 patients treated at the Kobe University Hospital and the Interhospital Cooperative Study Group for Multidisciplinary Approaches to Treatment of Pancreatic and Biliary Cancer. One hundred forty-three patients with pancreatic cancer were treated with a number of chemotherapeutic agents, while ninety-eight patients did not receive any chemotherapy. There were no significant differences in clinical characteristics between the two groups. The treated patients had a median survival time of 6 months and a one-year cumulative survival rate of 25.3%. These were significantly different compared with figures of 3 months and 9.5% for non-treated control patients. A chemotherapy regimen consisting of fluoropyrimidines was also confirmed to be effective. These results suggest that the chemotherapeutic approach appears quite promising and is effective for the treatment of pancreatic cancer.
基于神户大学医院及胰腺癌和胆管癌多学科治疗院际合作研究组治疗的299例患者的预后情况，对化疗在胰腺癌治疗中的效果进行了评估。143例胰腺癌患者接受了多种化疗药物治疗，而98例患者未接受任何化疗。两组患者的临床特征无显著差异。接受治疗的患者中位生存时间为6个月，1年累积生存率为25.3%。与未接受治疗的对照患者的3个月和9.5%的数据相比，这些数据有显著差异。由氟嘧啶组成的化疗方案也被证实是有效的。这些结果表明，化疗方法似乎很有前景，对胰腺癌的治疗是有效的。
