Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia , Katowice , Poland.
Department of Gynecological Endocrinology, Medical University of Silesia , Katowice , Poland.
Scand J Clin Lab Invest. 2019 Oct;79(6):419-423. doi: 10.1080/00365513.2019.1637535. Epub 2019 Jul 7.
One of the consequences of polycystic ovary syndrome (PCOS) is an increased risk of early development of cardiovascular diseases. Pentraxin-3 (PTX-3) is a new potential marker of endothelial dysfunction. The aim of the study was to assess PTX3 and other markers of endothelial dysfunction in PCOS women. The study enrolled 99 stable body mass PCOS women (17 normal weight, 21 overweight and 61 obese). Anthropometric measurements and serum/plasma levels of glucose, insulin, lipids, estradiol, testosterone, sex hormone binding globulin, 17-OH progesterone, free androgen index, pentraxin-3 (PTX3), soluble intercellular (sICAM-1) and vascular cell adhesion molecule 1 (sVCAM-1), endothelin-1 and total nitric oxide metabolites (tNO) concentrations were assessed. Groups were divided into tercile-subgroups according to PTX3 serum levels. Serum PTX3 tercile-subgroups significantly differed in respect to tNO, endothelin-1 and sVCAM-1, but not sICAM-1. The levels of tNO, endothelin-1 and sVCAM-1 were significantly decreased in the subgroup with the lowest PTX3 levels compared to both middle (tNO and endothelin 1) and upper tercile subgroups (all of them). There were significant positive correlations between log(PTX3) and log(tNO) ( = 0.34, < .001), log(endothelin-1) ( = 0.41, < .001) as well as sVCAM-1 levels ( = 0.22, < .05). Circulating PTX-3 levels seem to be a marker of endothelial dysfunction in PCOS women.
多囊卵巢综合征（PCOS）的后果之一是心血管疾病早期发展的风险增加。 正五聚蛋白 3（PTX-3）是内皮功能障碍的新的潜在标志物。本研究旨在评估 PCOS 女性的 PTX3 和其他内皮功能障碍标志物。该研究纳入了 99 名稳定体重的 PCOS 女性（17 名正常体重、21 名超重和 61 名肥胖）。评估了人体测量学指标以及血清/血浆中的葡萄糖、胰岛素、脂质、雌二醇、睾酮、性激素结合球蛋白、17-羟孕酮、游离雄激素指数、正五聚蛋白 3（PTX3）、可溶性细胞间黏附分子 1（sICAM-1）和血管细胞黏附分子 1（sVCAM-1）、内皮素-1 和总一氧化氮代谢物（tNO）浓度。根据 PTX3 血清水平将组分为三分位数亚组。PTX3 血清三分位数亚组在 tNO、内皮素-1 和 sVCAM-1 方面存在显著差异，但 sICAM-1 无差异。与中间（tNO 和内皮素 1）和上三分位数亚组（均为）相比，PTX3 水平最低的亚组的 tNO、内皮素-1 和 sVCAM-1 水平显著降低。log(PTX3)与 log(tNO)（ = 0.34， < .001）、log(内皮素-1)（ = 0.41， < .001）以及 sVCAM-1 水平之间存在显著正相关（ = 0.22， < .05）。循环 PTX-3 水平似乎是 PCOS 女性内皮功能障碍的标志物。
