The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, China.
Obstetrics & Gynecology Hospital, Institute of Reproduction and Development, Fudan University, 200011, Shanghai, China.
BMC Endocr Disord. 2021 Dec 3;21(1):240. doi: 10.1186/s12902-021-00886-4.
Pentraxin 3 (PTX3) - a crucial humoral innate immunity component - is related to obesity and cardiovascular complications in women who suffer from polycystic ovary syndrome (PCOS). However, the circulating PTX3 level in PCOS is still debated. In this study, we aimed to evaluate PTX3 plasma levels in PCOS women of childbearing age, and find possible endocrine/metabolic factors that could affect this level.
A total of 360 women were enrolled: 120 PCOS women and 240 body mass index (BMI) matched normally ovulating women. Blood samples were collected on the third day of natural menstrual cycle or from the bleeding after progesterone withdrawal. The PTX3 concentration was measured by immunoassay.
The PTX3 plasma level was significantly higher in PCOS women compared to controls. There was a positive correlation between PTX3 plasma level and PCOS diagnosis, overweight, cycle length, serum LH to FSH ratio, estradiol, total testosterone (TT) on the third day of menstrual cycle, antral follicle count (AFC), as well as uric acid. Multivariant linear regression analysis indicated that participants' serum PTX3 levels were proportional to the circulating TT level, existence of PCOS, basal estradiol level and AFC.
Overall, the circulating PTX3 level was elevated in PCOS women and significantly associated with the presence of hyperandrogenism. This study provided the basis for further in-depth researches regarding PTX3 role in PCOS pathophysiology.
Pentraxin 3（PTX3）是一种重要的体液固有免疫成分，与多囊卵巢综合征（PCOS）女性的肥胖和心血管并发症有关。然而，PCOS 患者的循环 PTX3 水平仍存在争议。在这项研究中，我们旨在评估育龄期 PCOS 妇女的 PTX3 血浆水平，并寻找可能影响该水平的内分泌/代谢因素。
共纳入 360 名妇女：120 名 PCOS 妇女和 240 名体重指数（BMI）匹配的正常排卵妇女。在自然月经周期的第 3 天或黄体酮撤退后出血时采集血样。通过免疫测定法测量 PTX3 浓度。
与对照组相比，PCOS 妇女的 PTX3 血浆水平显着升高。PTX3 血浆水平与 PCOS 诊断、超重、周期长度、血清 LH/FSH 比值、雌二醇、月经周期第 3 天的总睾酮（TT）、窦卵泡计数（AFC）以及尿酸呈正相关。多元线性回归分析表明，参与者的血清 PTX3 水平与循环 TT 水平、PCOS 的存在、基础雌二醇水平和 AFC 成正比。
总体而言，PCOS 妇女的循环 PTX3 水平升高，与高雄激素血症密切相关。本研究为进一步深入研究 PTX3 在 PCOS 病理生理学中的作用提供了依据。
