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精神分裂症中的努力目标导向行为:计算亚型与认知的关联。

Effortful goal-directed behavior in schizophrenia: Computational subtypes and associations with cognition.

机构信息

Department of Psychology.

Department of Psychological and Brain Sciences.

出版信息

J Abnorm Psychol. 2019 Oct;128(7):710-722. doi: 10.1037/abn0000443. Epub 2019 Jul 8.

Abstract

Schizophrenia is associated with amotivation and reduced goal-directed behavior, which have been linked to poor functional outcomes. Motivational deficits in schizophrenia are often measured using effort-based decision-making (EBDM) paradigms, revealing consistent alterations in effort expenditure relative to controls. Although these results have generally been interpreted in terms of decreased motivation, the ability to use trial-by-trial changes in reward magnitude or probability of receipt to guide effort allocation may also be affected by cognitive deficits. To date, it remains unclear whether altered performance in EBDM primarily reflects deficits in motivation, cognitive functioning, or both. We applied a newly developed computational modeling approach to the analysis of EBDM data from two previously collected samples comprising 153 patients and 105 controls to determine the extent to which individuals did or did not use available information about reward and probability to guide effort allocation. Half of the participants with schizophrenia failed to incorporate information about reward and probability when making effort-expenditure decisions. The subset of patients who exhibited difficulties using reward and probability information were characterized by greater impairments across measures of cognitive functioning. Interestingly, even within the subset of patients who successfully used reward and probability information to guide effort expenditure, higher levels of negative symptoms related to motivation and avolition were associated with greater effort aversion during the task. Taken together, these data suggest that prior reports of aberrant EBDM in schizophrenia patients are related to both cognitive function and individual differences in negative symptoms. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

摘要

精神分裂症与动机不足和目标导向行为减少有关,这些与不良的功能结果有关。精神分裂症的动机缺陷通常使用基于努力的决策(EBDM)范式进行测量,与对照组相比,努力支出显示出一致的改变。尽管这些结果通常被解释为动机降低,但根据奖励幅度或获得概率的逐次变化来指导努力分配的能力也可能受到认知缺陷的影响。迄今为止,尚不清楚 EBDM 中的改变表现主要反映了动机还是认知功能的缺陷,或者两者兼而有之。我们应用一种新开发的计算建模方法来分析来自两个先前收集的样本的 EBDM 数据,这些样本包含 153 名患者和 105 名对照者,以确定个体在多大程度上利用了关于奖励和概率的可用信息来指导努力分配。一半的精神分裂症患者在进行努力支出决策时未能整合关于奖励和概率的信息。表现出使用奖励和概率信息困难的患者亚组在认知功能的各个测量指标上都有较大的损伤。有趣的是,即使在成功使用奖励和概率信息来指导努力支出的患者亚组中,与动机和意志缺乏相关的较高水平的消极症状与任务期间更大的努力回避有关。总之,这些数据表明,先前报道的精神分裂症患者异常的 EBDM 与认知功能和消极症状的个体差异有关。(PsycINFO 数据库记录(c)2019 APA,保留所有权利)。

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