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综合心理治疗(IPT)在中年慢性精神分裂症住院患者中的实施与效果

The implementation and effectiveness of Integrated Psychological Therapy (IPT) in chronic middle-aged inpatients with schizophrenia.

作者信息

Poulou Aikaterini, Anagnostopoulos Fotios, Vatakis Argiro, Mellon Robert C, Mueller Daniel R

机构信息

Department of Psychology, Panteion University of Social and Political Sciences, Athens, Greece.

University Clinic of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.

出版信息

Schizophr Res Cogn. 2024 Sep 21;39:100330. doi: 10.1016/j.scog.2024.100330. eCollection 2025 Mar.

Abstract

INTRODUCTION

Cognitive rehabilitation is essential for schizophrenia treatment since it improves function. Moreover, the relationship between cognitive rehabilitation and functioning is significantly affected by negative symptoms and social cognition. Integrated Psychological Therapy (IPT) is a promising approach that integrates interventions in neurocognition, social cognition, and functional level. This study examines IPT's efficacy in chronic middle-aged inpatients.

METHODS

A randomized controlled study involved 44 individuals with schizophrenia. Twenty-one IPT participants received 50 biweekly sessions and medication, while twenty-three control participants received treatment as usual/supportive therapy and pharmacotherapy. Pre- and post-intervention and six- and twelve-month follow-ups were arranged to assess neurocognition, social perception, psychopathology, and functioning using the Matrics Consensus Cognitive Battery, Social Perception Scale, Positive and Negative Syndrome Scale, and Global Assessment of Functioning.

RESULTS

Speed of processing, attention/vigilance, overall composite, and neurocognitive composite scores improved significantly in the IPT group. Social Perception Scale performance improved in all areas after the intervention and persisted for 6 months. Positive, negative, and total psychopathology symptoms decreased significantly post-intervention and at the 12-month follow-up, whereas participants' functioning improved significantly.

CONCLUSIONS

Middle-aged chronic inpatients with schizophrenia may benefit from IPT in neurocognition, social perception, psychopathology, and functioning. This field of study may provide insight into schizophrenia treatment, hence further research is encouraged.

摘要

引言

认知康复对精神分裂症治疗至关重要,因为它能改善功能。此外,认知康复与功能之间的关系受阴性症状和社会认知的显著影响。综合心理治疗(IPT)是一种有前景的方法,它整合了神经认知、社会认知和功能水平方面的干预措施。本研究考察IPT对中年慢性住院患者的疗效。

方法

一项随机对照研究纳入了44名精神分裂症患者。21名接受IPT的参与者接受了50次每两周一次的治疗及药物治疗,而23名对照参与者接受常规治疗/支持性治疗及药物治疗。在干预前后以及6个月和12个月随访时,使用矩阵共识认知量表、社会感知量表、阳性和阴性症状量表以及功能总体评估来评估神经认知、社会感知、精神病理学和功能。

结果

IPT组的处理速度、注意力/警觉性、总体综合得分和神经认知综合得分有显著改善。干预后,社会感知量表在所有领域的表现均有改善,并持续了6个月。干预后及12个月随访时,阳性、阴性和总体精神病理学症状显著减少,而参与者的功能有显著改善。

结论

中年慢性精神分裂症住院患者可能从IPT在神经认知、社会感知、精神病理学和功能方面的治疗中获益。该研究领域可能为精神分裂症治疗提供见解,因此鼓励进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c321/11439836/fdf3022e9ad0/gr1.jpg

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