正常组织与肿瘤组织中脂质过氧化的研究。吉田大鼠肝癌
Studies on lipid peroxidation in normal and tumour tissues. The Yoshida rat liver tumour.
作者信息
Cheeseman K H, Emery S, Maddix S P, Slater T F, Burton G W, Ingold K U
机构信息
Department of Biochemistry, Faculty of Science, Brunel University, Uxbridge, Middlesex, U.K.
出版信息
Biochem J. 1988 Feb 15;250(1):247-52. doi: 10.1042/bj2500247.
Abstract
Reduced rates of lipid peroxidation have been observed in Yoshida hepatoma cells and microsomes when compared with appropriate control tissue (normal rat liver) under the same pro-oxidant conditions. The pro-oxidant conditions used were incubation with NADPH+ADP+iron or ascorbate+iron or exposure to gamma-irradiation. As previously shown with the Novikoff hepatoma, the relative concentrations of alpha-tocopherol and polyunsaturated fatty acids are important in conferring resistance to lipid peroxidation in the Yoshida hepatoma. Furthermore, NADPH-cytochrome c reductase and the NADPH-cytochrome P-450 electron transport chain, which are involved in the initiation and propagation of certain types of lipid peroxidation, are found at very much reduced levels in the Yoshida hepatoma. The relative importance of these aberrations are discussed.
摘要
与相同促氧化剂条件下的合适对照组织（正常大鼠肝脏）相比，吉田肝癌细胞和微粒体中的脂质过氧化速率降低。所使用的促氧化剂条件为与NADPH + ADP + 铁或抗坏血酸 + 铁一起孵育，或暴露于γ射线。如先前在诺维科夫肝癌中所示，α-生育酚和多不饱和脂肪酸的相对浓度对于赋予吉田肝癌对脂质过氧化的抗性很重要。此外，参与某些类型脂质过氧化起始和传播的NADPH-细胞色素c还原酶和NADPH-细胞色素P-450电子传递链在吉田肝癌中的水平非常低。讨论了这些异常的相对重要性。
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