Biomedical Materials Group, Institute of Pharmacy , Martin Luther University Halle-Wittenberg , Heinrich Damerow Strasse 4 , 06120 Halle (Saale), Germany.
Interdisciplinary Center of Material Science , Martin Luther University Halle-Wittenberg , Heinrich Damerow Strasse 4 , 06120 Halle (Saale), Germany.
ACS Appl Mater Interfaces. 2019 Jul 24;11(29):25637-25653. doi: 10.1021/acsami.9b06253. Epub 2019 Jul 8.
Toward imitating the natural smartness and responsivity of biological systems, surface interfacial properties are considered to be responsive and tunable if they show a reactive behavior to an environmental stimulus. This is still quite different from many contemporary biomaterials that lack responsiveness to interact with blood and different body tissues in a physiological manner. Meanwhile it is possible to even go one step further from responsiveness to dual-mode switchability and explore "switchable" or "reversible" responses of synthetic materials. We understand "switchable biomaterials" as materials undergoing a stepwise, structural transformation coupled with considerable changes of interfacial and other surface properties as a response to a stimulus. Therewith, a survey on stimuli-induced dynamic changes of , , , , , and is presented here, as potentially powerful new technologies especially for future biomaterial development. Since living cells constantly sense their environment through a variety of surface receptors and other mechanisms, these obedient interfacial properties were particularly discussed regarding their advantageous multifunctionality for protein adsorption and cell adhesion signaling, which may alter in time and with environmental conditions.
为了模仿生物系统的自然智能和响应性，如果表面界面特性表现出对环境刺激的反应行为，那么它们被认为是具有响应性和可调节性的。这与许多当代生物材料有很大的不同，许多当代生物材料缺乏对血液和不同身体组织的生理响应能力。同时，如果从响应性进一步发展到双模切换性，探索合成材料的“可切换”或“可逆”响应是可能的。我们将“可切换生物材料”理解为材料在响应刺激时经历逐步的、结构的转变，同时伴随着界面和其他表面性质的显著变化。因此，这里介绍了刺激诱导的动态变化的综述，包括氢键、离子键、范德华力、配位键和主客体相互作用，这些都是有前途的新技术，特别是对于未来的生物材料开发。由于活细胞通过各种表面受体和其他机制不断感知其环境，因此特别讨论了这些顺从的界面特性，因为它们在蛋白质吸附和细胞黏附信号传导方面具有有利的多功能性，这些特性可能会随着时间和环境条件的变化而改变。
