Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA; email:
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Annu Rev Genet. 2019 Dec 3;53:67-91. doi: 10.1146/annurev-genet-120116-024603. Epub 2019 Jul 5.
Cell-cell fusion is indispensable for creating life and building syncytial tissues and organs. Ever since the discovery of cell-cell fusion, how cells join together to form zygotes and multinucleated syncytia has remained a fundamental question in cell and developmental biology. In the past two decades, myoblast fusion has been used as a powerful genetic model to unravel mechanisms underlying cell-cell fusion in vivo. Many evolutionarily conserved fusion-promoting factors have been identified and so has a surprising and conserved cellular mechanism. In this review, we revisit key findings in myoblast fusion and highlight the critical roles of cellular invasion and resistance in driving cell membrane fusion.
细胞融合对于生命的创造和细胞融合组织和器官的构建是不可或缺的。自从发现细胞融合以来，细胞如何结合形成受精卵和多核合胞体一直是细胞和发育生物学中的一个基本问题。在过去的二十年中，成肌细胞融合已被用作一种强大的遗传模型，用于揭示体内细胞融合的机制。已经鉴定出许多进化上保守的促进融合的因素，以及一种令人惊讶和保守的细胞机制。在这篇综述中，我们重新审视了成肌细胞融合的关键发现，并强调了细胞侵袭和抵抗在驱动细胞膜融合中的关键作用。
